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Effects of various sequences of ATP synthesis inhibition in KHB group |
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| Sequences |
IAA following by KCN |
KCN following by IAA |
Simultaneous IAA+KCN |
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|
|
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| IAA |
KCN |
KCN |
IAA |
IAA+KCN |
|
|
|
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| Residual ATP content (% of the initial value) |
90% |
0 |
20–40% |
0 |
0 |
| Residual mitochondrial VO2(% of the initial value) |
110% (transient) |
0 |
0 |
0 |
0 |
| Initial rate of ATP hydrolysis* |
ND |
1.5 |
1.0 |
ND |
1.0 |
|
|
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| Total inhibition of: |
Glycolysis only |
OP only |
OP only |
Glycolysis only |
Glycolysis and OP simultaneously |
|
* arbitrary units; 1.0 corresponding to the rate of ATP decrease in simultaneous IAA+KCN sequence (1.09 ± 0.13 μmol/min.g liver wet weight). OP = oxidative phosphorylation. | |||||
Gallis et al. BMC Physiology 2007 7:8 doi:10.1186/1472-6793-7-8 |
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