Figure 1.

Serum TNFα Levels After IP LPS Challenge. LPS did not significantly alter expression of the transgene but dose-dependently increased endogenous TNFα in WT and TG mice similarly. WT (open bars) and TG mice (closed bars) were injected with the indicated doses of LPS (μg/mouse) as shown on the X-axis. (A) Human and (B) mouse TNFα levels were measured using ELISA assays. Data are presented as means ± SEM, n = 5 for each genotype and dose combination. ND – non-detectable.