Open Access Research article

Genomic homeostasis is dysregulated in favour of apoptosis in the colonic epithelium of the azoxymethane treated rat

Caroline A Kerr126*, Barney M Hines13, Janet M Shaw12, Robert Dunne14, Lauren M Bragg14, Julie Clarke15, Trevor Lockett12 and Richard Head1

Author Affiliations

1 CSIRO Preventative Health Flagship, CSIRO, North Ryde, NSW 2113, Australia

2 CSIRO, Food and Nutritional Sciences, North Ryde, NSW 2113, Australia

3 CSIRO Division of Livestock Industries, Queensland Biosciences Precinct, St Lucia, Queensland 4067, Australia

4 CSIRO, Mathematical and Information Sciences, North Ryde, New South Wales 1670, Australia

5 CSIRO Food and Nutritional Sciences, Adelaide 5000, South Australia

6 Graduate School of Medicine, University of Wollongong, Wollongong, NSW, Australia

For all author emails, please log on.

BMC Physiology 2013, 13:2  doi:10.1186/1472-6793-13-2

Published: 23 January 2013

Additional files

Additional file 1: Table S1:

The complete listing of transcript contrasts between proximal and distal in the normal epithelium (saline); between saline and AOM epithelium in the proximal and between saline and AOM epithelium in the distal colon. Table S2. A) Genes with Gene Ontology Biological Processing term associated with DNA damage and repair in the AOM versus saline contrast in the proximal colon. B) Genes with Gene Ontology Biological Processing term associated with DNA damage and repair in the AOM versus saline contrast in the distal colon. Table S3. Summary of genes validated by real time PCR for microarray differential expression. Genes: UDP-GlcNAc: betaGal beta-1,3-N-acetylglucosaminyltransferase 7, solute carrier family 34 (sodium phosphate), member 2; similar to N-acetylglucosamine 6-O-sulfotransferase (predicted), peroxiredoxin 6, homeo box D10 (predicted), protein kinase, cAMP dependent, catalytic, beta; cytochrome P450, family 4, subfamily f, polypeptide 1 and cancer susceptibility candidate 4 (predicted). Table S4: Details of the genes expressed in the p53 signaling pathway.

Format: PDF Size: 152KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data