Chronic BCG instillation increases IR for the pan neuronal marker, PGP9.5, and sensory nerve markers, TRPV1, SP, and CGRP. Quantification of PGP9.5- TRVP1-, SP-, and CGRP-IR in the sub urothelium (A) and detrusor muscle (B) of bladders isolated from: control (mice receiving i.p. PBS [twice a week] concomitant to 4 weekly instillations of PBS) and BCG-inflamed mice (mice receiving i.p. PBS [twice a week] concomitant to 4 weekly instillations of BCG). N = 8 per group. Statistical significance was set for p values < 0.05. NS = non significant.
Saban et al. BMC Physiology 2011 11:16 doi:10.1186/1472-6793-11-16