VEGF induces bladder inflammation. Quantification of myeloperoxidase-IR (A-B) and F4/80-IR (C-D) in the sub urothelium and detrusor muscle of bladders isolated from: 4 weekly instillations with PBS, single instillation with VEGF165, 4 weekly instillations with VEGF165, 6 weekly instillations with VEGF165, a single instillation with VEGF121, and 4 weekly instillations of VEGF121. Mice were euthanized one week after the last instillation and the urinary bladders removed for IF. N = 8 per group. Statistical significance was set for p values < 0.05.
Saban et al. BMC Physiology 2011 11:16 doi:10.1186/1472-6793-11-16