BMC Physiology


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The effect of marathon on mRNA expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners

Gabriella Marfe1*, Marco Tafani2, Bruna Pucci2, Carla Di Stefano1, Manuela Indelicato2, Angela Andreoli3, Matteo A Russo2,4, Paola Sinibaldi-Salimei1 and Vincenzo Manzi5

Author Affiliations

1 Department of Experimental Medicine and Biochemical Sciences, University of Rome "Tor Vergata" Via Montpellier 1, 00133, Rome, Italy

2 Department of Cellular and Molecular Pathology, IRCCS San Raffaele Pisana, Via dei Bonacolsi snc, 00163, Rome, Italy

3 Human Nutrition Unit, University of Rome "Tor Vergata" Via Montpellier 1, 00133, Rome, Italy

4 Department of Experimental Medicine, La Sapienza University, Viale Regina Elena 324, 00161, Rome, Italy

5 School of Sport and Exercise Sciences, University of Rome Tor Vergata" Via Columbia s.n.c. 00133 Rome, Italy

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BMC Physiology 2010, 10:7 doi:10.1186/1472-6793-10-7

Published: 12 May 2010

Additional files

Additional file 1:

The anti and pro-apoptotic and SIRTs mRNAs in healthy amateur runners who did not participate in the marathon. The results show the DNA fragmentation and the bax, bcl-2 SIRT1, SIRT3 RNA levels in six healthy amateur runners (who did not participate in the marathon) samples before and after marathon.

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Additional file 2:

Figure 1. DNA laddering

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Additional file 3:

Figure 2. Bax, bcl-2, SIRT1 and SIRT3 RNA levels were estimated by Northern Blot

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