Table 4

Summary of interacting partner analysis for human orthologs of 28 rat or mouse proteins commonly targeted by multiple different reactive metabolites a

Entrez id

Gene symbol

Human Protein name

Number of interacting partner proteins found


213

ALB

Albumin

12

217

ALDH2

Aldehyde dehydrogenase 2

7

383

ARG1

Arginase

2

761

CA3

Carbonic anhydrase III

3

2023

ENO1

Enolase 1

6

2168

FABP1

Fatty acid binding protein 1

2

2923

PDIA3

Protein disulfide isomerase A3

11

2944

GSTM1

Glutathione S-transferase Mu-1

4

2946

GSTM2

Glutathione S-transferase Mu-2

4

3309

HSPA5

BIP

31

3312

HSPA8

Heat shock 70 kDa protein 8

43

3417

IDH1

Isocitrate dehydrogenase 1

1

5034

P4HB

Protein disulfide isomerase

15

5037

PEBP1

Raf kinase inhibitor protein

18

5230

PGK1

Phosphoglycerate kinase 1

4

7170

TPM3

Tropomyosin 3

13

7276

TTR

Transthyretin

14

7295

TXN

Thioredoxin

10

8991

SELENBP1

Selenium binding protein 1

4

10130

PDIA6

Protein disulfide isomerase P5

2

10961

ERP29

Endoplasmic reticulum protein 29

4

1109

AKR1C4

Aldo keto reductase family 1, member C4

0

1652

DDT

D-dopachrome tautomerase

0

2052

EPHX1

Epoxide hydrolase

0

2184

FAH

Fumarylacetoacetase

0

2593

GAMT

Guanidinoacetate N-methyltransferase

0

10247

HRSP12

Translational inhibitor protein p14.5

0

51733

UPB1

Beta ureidopropionase

0


a No interacting partners were found for 7 of the 28 proteins. See Additional file 5 for full listing of all the interacting partners found.

Fang et al. BMC Chemical Biology 2009 9:5   doi:10.1186/1472-6769-9-5

Open Data