Table 2

Representative Gene Ontology terms significantly enriched in target proteins.a

GO-ID

Category Description

Corrected p-value

Number of target proteins selected

Total number of proteins in category

Fraction of population as targets


Molecular Function

3824

catalytic activity

1.45E-19

115

5085

0.023

16491

oxidoreductase activity

2.76E-12

40

916

0.044

16209

antioxidant activity

2.93E-09

11

57

0.193

51920

peroxiredoxin activity

9.34E-08

5

6

0.833

16684

oxidoreductase activity, acting on peroxide as acceptor

5.71E-07

8

40

0.20

4364

glutathione transferase activity

3.30E-06

7

34

0.206

9031

thioredoxin peroxidase activity

3.30E-06

4

5

0.8

51082

unfolded protein binding

9.02E-05

9

115

0.078

5504

fatty acid binding

9.42E-04

5

37

0.135

Biological Process

19752

carboxylic acid metabolic process

1.10E-14

35

524

0.067

6519

amino acid and derivative metabolic process

1.02E-08

23

362

0.064

9308

amine metabolic process

1.53E-08

24

414

0.058

6950

response to stress

4.82E-08

36

978

0.0369

6805

xenobiotic metabolic process

2.31E-07

8

32

0.25

9410

response to xenobiotic stimulus

2.74E-07

8

33

0.242

6979

response to oxidative stress

4.38E-07

12

110

0.109

6457

protein folding

1.28E-06

15

207

0.072

Cellular Component

5737

cytoplasm

4.59E-26

108

3936

0.027

44444

cytoplasmic part

3.71E-23

91

2969

0.031

5739

mitochondrion

2.31E-16

41

750

0.055

5788

endoplasmic reticulum lumen

4.95E-10

8

20

0.4

5829

cytosol

2.95E-09

25

494

0.051

5783

endoplasmic reticulum

9.68E-09

25

525

0.048

5793

ER-Golgi intermediate compartment

2.07E-06

6

23

0.261

5625

soluble fraction

2.56E-06

15

260

0.058


a GO analysis was performed using BinGO in Cytoscape. The rat proteome was used as the background for comparison. A complete listing of terms having a false discovery rate (FDR) < 1.0E-03 is presented in Table S3 (see Additional file 5). Also available in the Additional files are graphic representations of enriched GO categories and their hierarchical structures (Figures S1 and S2 in Additional files 1 and 2, respectively).

Fang et al. BMC Chemical Biology 2009 9:5   doi:10.1186/1472-6769-9-5

Open Data