Activation of reporter constructs by pro-apoptotic compounds. Four different CellSensor® HCT116 cell lines (Invitrogen) were treated with 40 different pro-apoptotic compounds and stimulation of reporter activity measured at 4 and 16 hours. Maximal stimulation at 4 or 16 hours time-point is illustrated graphically (yellow squares: >2-fold activation; orange squares: >3-fold activation; red squares: >5-fold activation).
Olofsson et al. BMC Chemical Biology 2008 8:2 doi:10.1186/1472-6769-8-2