Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol

doi:10.1186/1472-6769-6-2

BMC Chemical Biology

Volume 6

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Research article

Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol

Zoltan Maliga¹ and Timothy J Mitchison²

¹MPI-CBG, Pfotenhauer Strasse 108, 01307 Dresden, Germany

²Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA

author email corresponding author email

BMC Chemical Biology 2006, 6:2doi:10.1186/1472-6769-6-2


Published:	27 February 2006

Additional files

Additional File 1:

Atomic structure determination of the Eg5-monastrol-ADP complex using multi-wavelength anomalous dispersion (PDB 1X88). Materials and methods for determination of Eg5-monastrol-ADP co-crystal structure using selenomethionine-labeled Eg5 motor domain as independent verification of published structure [25].

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Additional File 2:

Crystallographic data and refinement statistics for structure of Eg5-monastrol-ADP complex (PDB: 1X88).

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