Table 1

Multiple sequence alignment showing conservation of the EDGEECDCGE motif in all known mammalian forms of ADAM19 and a homologous putative ADAM in fission yeast (top). Multiple sequence alignment showing proposed Cr(III) binding sequence, NKDDNEECGD, conserved in the insulin receptor (INSR) across species, but not in the insulin-like growth factor receptor (IG1R) (bottom).

SwissProt

Protein

Species

Sequence


Q9H013

ADAM19

Human

GNGYL

    EDGEECDCGEEEE
CNNP

O35674

ADAM19

Mouse

GNGYL

    EDGEECDCGEEEE
CNNP

ADAM19

Rat

GNGYL

    EDGEECDCGEEDE
CKNP

O13766

Homolog

S. Pombe

GNGIV

    EDGEECDCGEDCE
NNPC


P15208

INSR

Mouse

NKDDN

    EECGD
VCPGT

P15127

INSR

Rat

NKDDN

    EECGD
VCPGT

P06213

INSR

Human

NKDDN

    EECGD
ICPGT

Q9PVZ4

Homolog

Xenopus

NRDNK

    EECGD
VCPGT

Q60751

IG1R

Mouse

NKPPKECGDLCPGTL

P24062

IG1R

Rat

NKPPKECGDLCPGTL

P08069

IG1R

Human

NKPPKECGDLCPGTL

O73798

Homolog

Xenopus

NKPPKECVDLCPGA.


Dinakarpandian et al. BMC Chemical Biology 2004 4:2   doi:10.1186/1472-6769-4-2

Open Data