Degradation of 5' end-labelled Mrz-12/12 A in RPMI + 10% human serum at 37°C. Time of incubation in indicated above each lane. OH-indicates an alkaline digest of the same material. FL indicates the position of the full-length miniribozyme. The position of the fragments terminating at each of the ribonucleotides is indicated by the letters adjacent to the alkaline digest.
Hendry et al. BMC Chemical Biology 2004 4:1 doi:10.1186/1472-6769-4-1