Table 3

Kinase profiling report for CID755673

    CID755673, 10 μM

    CID755673, 10 μM

Kinase

Average % Inhibition

Kinase

Average % Inhibition


ABL

8

KDR

8

AKT1

3

MAPKAPK2

95

AKT2

4

MARK1

12

AMPK

35

MET

18

AurA

7

MSK1

7

BTK

-3

p38a

2

CAMK4

17

p70S6K

44

CDK2

71

PAK2

3

CHK1

7

PDGFRα

5

CHK2

4

PDK1

22

CK1δ

82

PIM2

6

c-Raf

2

PKA

6

EGFR

11

PKCη

40

ErbB4

1

PKCγ

30

Erk1

50

PKCθ

32

Erk2

31

PKCζ

-4

FGFR1

16

PKD2

95

FLT3

14

PKG1α

13

GSK3β

86

PKG1β

11

IGF1R

-2

MK5/PRAK

75

Ikkb

49

RSK1

29

IBSR

3

SGK1

9

IRAK4

0

SRC

7

JNK2

36

SYK

-8


48 kinases were interrogated using a single-dose in vitro kinase assay at 10 μM CID755673. -20 to +20% inhibition, baseline levels; >20 to 49% inhibition, compound only marginally actively inhibits the kinase; >50% inhibition, compound is actively inhibiting the kinase. The assay was performed by Caliper Life Sciences (Hanover, MD).

LaValle et al. BMC Chemical Biology 2010 10:5   doi:10.1186/1472-6769-10-5

Open Data