Table 5 |
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Genes down-regulated (≥ 3-fold vs LPS activation alone) by 10 μM PEO in macrophages |
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Gene name abbreviation |
Gene name full |
Partial Gene Ontology term |
Fold change in response to LPS |
|
|
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CCL2* |
Chemokine (C-C motif) ligand 2 |
Inflammatory response; Chemokine activity |
-35.67 |
|
CSF2 |
Colony stimulating factor 2 (granulocyte- macrophage) |
Immune response; Cytokine and chemokine mediated signaling pathway |
-8.21 |
|
CSF3 |
Colony stimulating factor 3 (granulocyte) |
Immune response; Cytokine activity |
-53.69 |
|
CXCL10* |
Chemokine (C-X-C motif) ligand 10 |
Inflammatory response; Chemokine activity |
-30.05 |
|
FOS |
FBJ osteosarcoma oncogene |
DNA binding; Regulation of transcription |
-10.90 |
|
GJA1 |
Gap junction membrane channel protein alpha 1 |
Cell-cell signaling |
-19.25 |
|
IL10 |
Interleukin 10 |
Immune response; Cytokine activity |
-4.95 |
|
IL1a |
Interleukin 1 alpha |
Inflammatory response; Cytokine activity |
-291.36 |
|
IL1b |
Interleukin 1 beta |
Inflammatory response; Cytokine activity; Neutrophil chemotaxis; Positive regulation of IL-6 and chemokine biosynthesis |
-32.83 |
|
IL6* |
Interleukin 6 |
Signal transducer and cytokine activity |
-14.39 |
|
MAPK3 |
Mitogen activated protein kinase 3 |
ATP binding; Transferase activity; Protein amino acid phosphorylation; Signal transduction; Inflammatory response; Regulation of cytokine biosynthesis; MAP kinase activity |
-3.11 |
|
NFkB1 |
Nuclear factor of kappa light chain gene enhancer in B-cells 1, p105 |
DNA binding; Regulation of transcription |
-21.51 |
|
NFkB2 |
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 |
DNA binding; Regulation of transcription |
-5.72 |
|
NFkBia |
Nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha |
Nucleus; Protein binding; Cytoplasm: Regulation of cell proliferation; Protein-nucleus import, translocation |
-8.21 |
|
REL |
Reticuloendotheliosis oncogene |
DNA binding; Regulation of transcription |
-5.76 |
|
RELb |
Avian reticuloendotheliosis viral (v-rel) oncogene related B |
Transcription factor activity; Intracellular; T-helper 1 type immune response |
-3.78 |
|
RIPK2 |
Receptor (TNFRSF)-interacting serine-threonine kinase 2 |
Regulation of apoptosis |
-5.72 |
|
SLC20a1* |
Solute carrier family 20, member 1 |
Receptor activity; Phosphate transport |
-6.81 |
|
STAT1* |
Signal transducer and activator of transcription 1 |
DNA binding; Regulation of transcription |
-4.81 |
|
TNFaip3* |
Tumor necrosis factor, alpha-induced protein 3 |
Apoptosis; Zinc ion binding |
-134.05 |
|
CD40* |
CD40 antigen |
Signal transduction; Immune response; Apoptosis |
-46.74 |
|
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* Novel hits (genes) suppressed by PEITC/PEO (previously not reported) |
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Dey et al. BMC Chemical Biology 2010 10:4 doi:10.1186/1472-6769-10-4 |
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