BMC Biotechnology

official impact factor 2.86
Search for
Advanced search
BMC Biotechnology
Tools
Share this article
Open Access Research article

Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice

Irene Bergwerf1,2, Nathalie De Vocht1,2,3, Bart Tambuyzer1,2, Jacob Verschueren3, Kristien Reekmans1,2,9, Jasmijn Daans1,2, Abdelilah Ibrahimi10,4, Viggo Van Tendeloo1,2,9, Shyama Chatterjee5, Herman Goossens2, Philippe G Jorens6,9, Veerle Baekelandt10,7, Dirk Ysebaert8,9, Eric Van Marck5, Zwi N Berneman1,2,9, Annemie VD Linden3 and Peter Ponsaerts1,2,9*

Author Affiliations

1 Laboratory of Experimental Hematology, University of Antwerp, Antwerp, Belgium

2 Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium

3 Bio-Imaging Laboratory, University of Antwerp, Antwerp, Belgium

4 Laboratory for Molecular Virology & Gene Therapy, Katholieke Universiteit Leuven, Leuven, Belgium

5 Laboratory of Pathology, University of Antwerp, Antwerp, Belgium

6 Clinical Pharmacotherapy, University of Antwerp, Antwerp, Belgium

7 Laboratory for Neurobiology & Gene Therapy, Katholieke Universiteit Leuven, Leuven, Belgium

8 Laboratory of Experimental Surgery, University of Antwerp, Antwerp, Belgium

9 Centre for Cellular Therapy and Regenerative Medicine (CCRG), Antwerp University Hospital, Antwerp, Belgium

10 Molecular Small Animal Imaging Centre (Mosaic), Katholieke Universiteit Leuven, Leuven, Belgium

For all author emails, please log on.

BMC Biotechnology 2009, 9:1 doi:10.1186/1472-6750-9-1

Published: 7 January 2009

Additional files

Additional file 1:

In vitro bioluminescence of cultured luciferase-expressing bone marrow-derived stromal cells using the Biospacein vivo bioluminescence camera. Additional data showing detection sensitivity of in vitro bioluminescence by luciferase-expressing bone marrow-derived stromal cells using the Biospace in vivo bioluminescence camera.

Format: PDF Size: 130KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

Histological analysis of luciferase-expressing ROSA26-L-S-L-Luc bone marrow-derived stromal cells following allogeneic transplantation in C57BL/6 mice. Additional data showing immunological rejection of luciferase-expressing ROSA26-L-S-L-Luc bone marrow-derived stromal cells following allogeneic transplantation in C57BL/6 mice.

Format: PDF Size: 1.6MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data