Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid

Dae-Kyun Ro^1* , Mario Ouellet^2* , Eric M Paradise³ , Helcio Burd² , Diana Eng⁴ , Chris J Paddon⁴ , Jack D Newman⁴ and Jay D Keasling^2,3,5,6

¹  Department of Biological Sciences, University of Calgary, Calgary, T2N 1N4, Canada

²  California Institute of Quantitative Biomedical Research, University of California, Berkeley, USA

³  Department of Chemical Engineering, University of California, Berkeley, 94720, USA

⁴  Amyris Biotechnologies, Emeryville, USA

⁵  Department of Bioengineering, University of California, Berkeley, USA

⁶  Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, USA