Figure 3.

The mean plasma concentration of HCPT after IV administration of HCPT or HCPT/PEG-PBLG nanospheres at a single dose of 12 mg/kg. The HCPT release profile from HCPT-loaded nanoparticles showed a biphasic with an initial abrupt release, followed by a sustained release. The abrupt release occurred at 1 h and the peak concentration was 1513.5 μg/L. The release then became sustained, with a plasma concentration between 84.7 and 7.4 μg/L.