Figure 9.

Mitogenic Activity of rhPln.247 and rhPln.198. HUVEC (panel A, C) or Baf32 cells (panel B) demonstrated a dose-dependent mitogenic response to rhPln.247 (panel A, B), or rhPln.198 (panel C). Panel B: Proliferation augmentation of FGFR1C expressing BAF32 cells by Pln.247 in the presence of 0.3 nM rhFGF-2 (solid). No proliferation enhancement was observed with Pln.247 without FGF-2 (crosshatch). In panel C, data represents the net absorbance for varying amounts of Pln.D1 with constant growth factor concentration after subtracting the contribution from Pln.D1 alone (without growth factor). Data are the average of four experiments.