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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor J. Ann Le Good PhD
Welcome to BMC Biotechnology published by BioMed Central
BMC Biotechnology is an open access journal publishing original peer-reviewed research articles in the manipulation of biological macromolecules or organisms for use in experimental procedures, cellular and tissue engineering or in the pharmaceutical, agricultural biotechnology and allied industries.
BMC Biotechnology (ISSN 1472-6750) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, EMBASE, Scopus, FSTA, Thomson Reuters (ISI) and Google Scholar.
Featured articles
BMC Biotechnology 2009, 9 :82
Production of human neurons in a bioreactor by in vitro expansion of human embryonic stem cells and fast differentiation into neurons demonstrates a scalable and efficient bioprocess for producing differentiated derivatives from stem cells.
BMC Biotechnology 2009, 9 :79
Chickens are protected from developing the economically-important illness coccidiosis by eating pea seeds expressing antibodies against the parasite Eimeria, showing passive immunization to be a cost-effective method of controlling this infectious disease.
BMC Biotechnology 2009, 9 :64
Stable nuclear transformation of the green alga Gonium pectorale, using promoter sequences from related species to drive expression of a selectable marker or reporter gene, opens the way to genetic engineering in this species.
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Research article
High-level HIV-1 Nef transient expression in Nicotiana benthamiana using the P19 gene silencing suppressor protein of Artichoke Mottled Crinckle Virus Raffaele Lombardi, Patrizia Circelli, Maria Elena Villani, Giampaolo Buriani, Luca Nardi, Valentina Coppola, Linda Bianco, Eugenio Benvenuto, Marcello Donini, Carla Marusic BMC Biotechnology 2009, 9 :96 (20 [Abstract ] [Provisional PDF ]
Research article
Quantifying and resolving multiple vector transformants in S. cerevisiae plasmid libraries Thomas C Scanlon, Elizabeth C Gray, Karl E Griswold BMC Biotechnology 2009, 9 :95 (20 [Abstract ] [Provisional PDF ]
Research article
Non-antibiotic selection systems for soybean somatic embryos:
the lysine analog aminoethyl-cysteine as a selection agent Suryadevara S. Rao, Lewamy Mamadou, Matt McConnell, Raghuveer Polisetty, Prachuab Kwanyuen, David Hildebrand BMC Biotechnology 2009, 9 :94 (18 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Genetic load and transgenic mitigating genes in transgenic Brassica rapa (field mustard) Brassica napus (oilseed rape) hybrid populations Christy W Rose, Reginald J Millwood, Hong S Moon, Murali R Rao, Matthew D Halfhill, Paul L Raymer, Suzanne I Warwick, Hani Al-Ahmad, Jonathan Gressel, C Neal Stewart Jr BMC Biotechnology 2009, 9 :93 (31 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Affinity maturation generates greatly improved xyloglucan-specific carbohydrate binding modules Laura von Schantz, Fredrika Gullfot, Sebastian Scheer, Lada Filonova, Lavinia Cicortas Gunnarsson, James E Flint, Geoffrey Daniel, Eva Nordberg-Karlsson, Harry Brumer, Mats Ohlin BMC Biotechnology 2009, 9 :92 (31 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Methodology article
Authentication scheme for routine verification of genetically similar laboratory colonies: a trial with Anopheles gambiae Elien E Wilkins, Paula L Marcet, Alice C Sutcliffe, Paul I Howell BMC Biotechnology 2009, 9 :91 (22 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Using a water-immiscible ionic liquid to improve asymmetric reduction of 4-(trimethylsilyl)-3-butyn-2-one catalyzed by immobilized Candida parapsilosis CCTCC M203011 cells Wen-Yong Lou, Lei Chen, Bo-Bo Zhang, Thomas J Smith, Min-Hua Zong BMC Biotechnology 2009, 9 :90 (22 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes Tanja Deurholt, Niek P van Til, Aniska A Chhatta, Lysbeth ten Bloemendaal, Ruth Schwartlander, Catherine Payne, John N Plevris, Igor M Sauer, Robert AFM Chamuleau, Ronald PJ Oude Elferink, Jurgen Seppen, Ruurdtje Hoekstra BMC Biotechnology 2009, 9 :89 (21 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Regulated expression of a transgene introduced on an oriP/EBNA-1 PAC shuttle vector into human cells Hanne A Askautrud, Elisabet Gjernes, Gro L St BMC Biotechnology 2009, 9 :88 (16 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Methodology article
Characterization of unknown genetic modifications using high throughput sequencing and computational subtraction Torstein Tengs, Haibo Zhang, Arne Holst-Jensen, Jon Bohlin, Melinka A Butenko, Anja Br BMC Biotechnology 2009, 9 :87 (8 [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research
The secretions of oviduct epithelial cells increase the equine in vitro fertilization rate: are osteopontin, atrial natriuretic peptide A and oviductin involved? Sylvie Mugnier, Morgane Kervella, Cecile Douet, Sylvie Canepa, Geraldine Pascal, Stefan Deleuze, Guy Duchamp, Philippe Monget, Ghylene Goudet Reproductive Biology and Endocrinology 2009, 7 :129 (19 [Abstract ] [Provisional PDF ]
Research article
Expression of TNF-related apoptosis-inducing ligand (TRAIL) in keratinocytes mediates apoptotic cell death in allogenic T cells Kerstin Reimers, Christine Radtke, Claudia Y Choi, Christina Allmeling, Susanne Kall, Paul Kiefer, Thomas Muhlberger, Peter M Vogt Annals of Surgical Innovation and Research 2009, 3 :13 (19 [Abstract ] [Provisional PDF ]
Research
Overexpression and characterization of medium-chain-length polyhydroxyalkanoate granule bound polymerases from Pseudomonas putida GPo1 Qun Ren, Guy de Roo, Bernard Witholt, Manfred Zinn, Linda Thony-Meyer Microbial Cell Factories 2009, 8 :60 (19 [Abstract ] [Provisional PDF ]
Research
Effective relief of neuropathic pain by adeno-associated virus-mediated expression of a small hairpin RNA against GTP cyclohydrolase 1 Sung Jin Kim, Won Il Lee, Yoon Sun Lee, Dong Hou Kim, Jin Woo Chang, Seong Who Kim, Heuiran Lee Molecular Pain 2009, 5 :67 (18 [Abstract ] [Provisional PDF ]
Methodology article
Nonlinear preprocessing method for detecting peaks from gas chromatograms Byonghyo Shim, Hyeyoung Min, Sungroh Yoon BMC Bioinformatics 2009, 10 :378 (18 [Abstract ] [Provisional PDF ]
Research article
Purification and characterization of cysteine protease from germinating cotyledons of horse gram Rajeswari Jinka, Vadde Ramakrishna, Sridhar K Rao, Ramakrishna P Rao BMC Biochemistry 2009, 10 :28 (17 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Comparative analysis of the complete sequence of the plastid genome of Parthenium argentatum and identification of DNA barcodes to differentiate Parthenium species and lines Shashi Kumar, Frederick M. Hahn, Colleen M. McMahan, Katrina Cornish, Maureen C. Whalen BMC Plant Biology 2009, 9 :131 (17 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Software article
Linear model for fast background subtraction in oligonucleotide microarrays K Myriam Kroll, Gerard T Barkema, Enrico Carlon Algorithms for Molecular Biology 2009, 4 :15 (16 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
Distinct population of highly malignant cells in a head and neck squamous cell carcinoma cell line established by xenograft model Chi-Yuan Chen, Shih-Hwa Chiou, Chih-Yang Huang, Chia-Ing Jan, Shu-Chun Lin, Ming-Long Tsai, Jeng-Fan Lo Journal of Biomedical Science 2009, 16 :100 (16 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
Cloning, expression in Pichia pastoris , and characterization of a thermostable GH5 mannan endo-1,4-Aspergillus niger BK01 Do Bien-Cuong, Dang Thi-Thu, Jean-Guy Berrin, Dietmar Haltrich, To Kim-Anh, Jean-Claude Sigoillot, Montarop Yamabhai Microbial Cell Factories 2009, 8 :59 (13 [Abstract ] [Full Text ] [PDF ] [PubMed ] [Related articles ]
Featured articles 
Brassica napus (oilseed rape) hybrid populations
rvold, Mona M Lindeberg, Jim Thorsen, Hans Prydz, Eirik Frengen
then Kristoffersen, Hilde-Gunn Opsahl Sorteberg, Knut G Berdal
-mannosidase from Aspergillus niger BK01