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Open Access Highly Accessed Case report

Acral peeling skin syndrome in two East-African siblings: case report

Samson K Kiprono1*, Baraka M Chaula1, Bernard Naafs12 and John E Masenga1

Author Affiliations

1 Department of Dermatology, Regional Dermatology Training Center at KCMC, Box 8332, Moshi, Tanzania

2 Stichting Tropendermatologie, Munnekeburen, The Netherlands

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BMC Dermatology 2012, 12:2  doi:10.1186/1471-5945-12-2

Published: 19 March 2012

Abstract

Background

Acral peeling skin syndrome is a rare autosomal recessive genodermatosis due to a missense mutation in transglutaminase 5. The skin peeling occurs at the separation of the stratum corneum from the stratum granulosum.

Case presentation

We present a case of two siblings who developed continuous peeling of the palms and soles from the first year of life. This peeling was more severe on the soles than palms and on younger sibling than elder sibling. Peeling is worsened by occlusion and sweating.

Conclusions

Sporadic cases of Acral Peeling Skin Syndrome occur in African population. There is variability in time of presentation and clinical severity even within families.

Keywords:
Acral peeling skin syndrome; African; Siblings