Comparison of in vivo knockdown of IL-12B and TNFα mRNA in xenografted psoriatic skin by lentiviral delivery of anti-IL12B and anti-TNFα shRNAs. Comparison of the effect of targeting IL-12B mRNA (black bars) and TNFα mRNA (white bars) in xenografted psoriatic skin by lentiviral delivery of cytokine-targeting shRNAs. mRNA knockdown: bars depict percentage down-regulation of IL-12B and TNFα mRNA, respectively, in the transduced grafts compared to the negative control group. Epidermal thickness: bars depict percentage reduction of epidermal thickness compared to the negative control (100% indicates reduction of epidermal thickness to that of average non-lesional skin). Clinical improvement: bars depict improvement of the semiquantitative clinical psoriasis score at treatment endpoint compared to the negative control (100% indicates complete disease resolution to non-lesional skin).
Bak et al. BMC Dermatology 2011 11:5 doi:10.1186/1471-5945-11-5