Table 1

PICOS Elements of the Review Protocol

Parameter

Inclusion Criteria

Exclusion Criteria


Participants

● Studies of participants diagnosed with Paget's disease (mammary or extramammary, invasive or non-invasive) and 18 years of age or older

● Studies of participants under 18 years of age


Intervention

● Any application of a photodynamic therapy alone or in conjunction with another therapy

● All wavelengths and light sources will be considered

● Any formulation of ALA, including experimental formulations

● MAL

● All intravenous photosensitizers

● None


Comparator

● All studies with or without comparators


Outcomes

● Any clinical outcome, including (but not restricted to): complete lesion eradication; cosmetic results; patient satisfaction; adverse effects and the need for additional therapy

● Studies without any defined clinical outcomes


Study Design

● Any study design including case series and case reports

● Review articles

● Economic evaluations

● Editorials and opinion pieces


Nardelli et al. BMC Dermatology 2011 11:13   doi:10.1186/1471-5945-11-13

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