|
Areas under the curves (AUC), specificities at 95% sensitivity and sensitivities at 95% specificity with the respective confidence intervals (in parenthesis) for the parameters tPSA, %fPSA, PSAD§, PSAV, ANN and ANNV$ for the tPSA range 4–10 ng/mL (n = 94) |
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| Parameter |
AUC (Confidence Intervals) |
P-values and significance levels§ |
Specificity at 95% Sensitivity |
P-values and significance levels§ |
Sensitivity at 95% Specificity |
P-values and significance levels$ |
|
|
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| PSA |
0.50 (0.36–0.63) |
<0.0001*** |
11.4 (5.9–19.8) |
0.002** |
4.2 (1.3–19.1) |
0.037* |
| %fPSA |
0.64 (0.51–0.77) |
0.09 |
20 (12.6–29.6) |
0.045* |
12.5 (3.5–29.7) |
0.023* |
| PSAD |
0.69 (0.58–0.81) |
- |
35.7 (26.2–46.2) |
- |
4.2 (1.3–19.1) |
0.013* |
| PSAV |
0.66 (0.53–0.80) |
0.529 |
4.3 (1.2–11.0) |
<0.0001*** |
12.5 (3.5–29.7) |
0.023* |
| ANN |
0.66 (0.53–0.79) |
0.264 |
8.6 (3.8–16.4) |
<0.0001*** |
16.7 (5.9–34.6) |
0.074 |
| ANNV |
0.57 (0.40–0.75) |
0.008** |
0 |
<0.0001*** |
37.5 (21.2–56.4) |
- |
|
§PSAD with largest AUC and highest specificity at 95% sensitivity, all others compared to PSAD $ANNV with highest sensitivity at 95% specificity, all others compared to ANNV *P < 0.05 **P < 0.01 ***P < 0.0001 | ||||||
Stephan et al. BMC Urology 2008 8:10 doi:10.1186/1471-2490-8-10 |
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