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Open Access Highly Accessed Research article

Frequency and patterns of early recanalization after vasectomy

Michel Labrecque1*, Melissa Hays2, Mario Chen-Mok2, Mark A Barone3 and David Sokal2

Author Affiliations

1 Evaluation Research Unit, D1-724, Centre de recherche du Centre Hospitalier Universitaire de Québec (CHUQ), Hôpital Saint-François d'Assise, 10, rue de l'Espinay, Québec, (Qc), G1L 3L5, Canada

2 Family Health International, 2224 East NC Highway 54, Durham, NC 27713, USA

3 EngenderHealth, 440 Ninth Ave. New York, NY 10001, USA

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BMC Urology 2006, 6:25  doi:10.1186/1471-2490-6-25

Published: 19 September 2006

Abstract

Background

Our understanding of early post-vasectomy recanalization is limited to histopathological studies. The objective of this study was to estimate the frequency and to describe semen analysis patterns of early recanalization after vasectomy.

Methods

Charts displaying serial post-vasectomy semen analyses were created using the semen analysis results from 826 and 389 men participating in a randomized trial of fascial interposition (FI) and an observational study of cautery, respectively. In the FI trial, participants were randomly allocated to vas occlusion by ligation and excision with or without FI. In the cautery study, sites used their usual cautery occlusion technique, two with and two without FI. Presumed early recanalization was based on the assessment of individual semen analysis charts by three independent reviewers. Discrepancies were resolved by consensus.

Results

Presumed early recanalization was characterized by a very low sperm concentration within two weeks after vasectomy followed by return to large numbers of sperm over the next few weeks. The overall proportion of men with presumed early recanalization was 13% (95% CI 12%–15%). The risk was highest with ligation and excision without FI (25%) and lowest for thermal cautery with FI (0%). The highest proportion of presumed early recanalization was observed among men classified as vasectomy failures.

Conclusion

Early recanalization, occurring within the first weeks after vasectomy, is more common than generally recognized. Its frequency depends on the occlusion technique performed.