HXR9 induces apoptosis in prostate cancer cells. (a) Caspase 3 activity in PC3, DU145, LNCaP and WPMY-1 cells treated with 60 μM HXR9 or CXR9 for two hours. ‘Unt’ - untreated cells; Y axis units: relative fluorescence (b) PC3, DU145, LNCaP and WPMY-1 cells were treated with 60 μM HXR9 (HX) or CXR9 (CX) for two hours and cells were assessed for apoptosis through Annexin/7AAD staining. The % of cells in apoptosis is shown. Cells were also treated with the Caspase inhibitor ZVAD (ZV) alone or in combination with HXR9 (HX ZV). Error bars show the SEM. *p < 0.05, **p < 0.01 with respect to untreated cells.
Morgan et al. BMC Urology 2014 14:17 doi:10.1186/1471-2490-14-17