EBP50 staining intensity by prostatic tissue type. A) Mean EBP50 staining score by prostatic tissue type. Significant differences were seen between Mets and NDP (p = 0.027), NAC (p < 0.001), BPH (p < 0.012), PIN (p < 0.001), and PCa (p = 0.006), with Mets having the lowest staining of any group. PIN also had the highest staining of any group, and was significantly higher than PCa (p < 0.001) and NAC (p < 0.009) groups. B) Box plots of EBP50 Staining Intensities by Tissue Type Featuring Individual Cases. It is especially notable that many specimens in the PCa and Mets classifications feature staining below that of the other tissue classifications. Moreover, only one case of Mets featured a score above 155, the lowest limit for high intensity staining.
Bartholow et al. BMC Urology 2011 11:12 doi:10.1186/1471-2490-11-12