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Association between gefitinib and hemorrhagic cystitis and severely contracted bladder: a case report

Maki Arakawa1, Kogenta Nakamura2*, Yoshiaki Yamada2, Charles J Rosser3, Motoi Tobiume2, Hiroko Saito1, Takaaki Hasegawa1 and Nobuaki Honda2

Author Affiliations

1 Department of Hospital Pharmacy, Aichi Medical University Hospital, Nagakute, Aichi 480-1195, Japan

2 Department of Urology, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan

3 Department of Urology, University of Florida, Gainesville, FL, USA

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BMC Urology 2010, 10:6  doi:10.1186/1471-2490-10-6

Published: 26 February 2010



Gefitinib remains an excellent treatment option for patients with a variety of cancers, including non small cell lung cancer (NSCLC). However, clinicians must be aware of the potential of gefitinib to cause an inflammatory reaction in the skin, lungs and bladder.

Case Presentation

We present a case on hemorrhagic cystitis and severaly contracted bladder in a patient with NSCLC on gefitinib.


Further studies are needed to substantiate the association of gefitinib therapy with hemorrhagic cystitis and contracted bladder.