Figure 4.

Age related occurrence of BC due to exposure to carcinogenic factors and BC-associated genetic changes. (A) Young BC patients, age <20, with a low carcinogenic exposure having chromosomal stable tumors, no mutations in FGFR3 and TP53 and no loss on chromosome 9. (B) Patients aged 20-60 with either a molecular profile corresponding to young (<20) or older (>60) patients. (C) Older BC patients with high exposure to carcinogenic factors and chromosomal unstable tumors, loss on chromosome 9, FGFR3 and TP53 mutations.