|
Tabulated summary of the specific analyses of failed or false negative analysis where such has been explicitly contained within the publication. |
||
| Authors |
Year |
Comment |
|
|
||
| Bendavid [56] |
2002 |
The one false negative case occurred in a patient with liver metastases. Also 'evidently metastatic nodes' did not receive colourant |
| Paramo [57] |
2002 |
No specific analysis presented. |
| Wood [58] |
2002 |
All five false negatives occurred in T3 or T4 tumors (in one case the only positive non-sentinel node was involved by direct extension). Three occurred in 1st 30 cases |
| Bilchik [59] |
2002 |
All five false negatives occurred in T3 or T4 tumors. Three occurred in the first fifty cases. |
| Kitagawa [60] |
2002 |
Four false negative cases were advanced T3 and/or had massive lymph node metastases |
| Feig [61] |
2002 |
Also 'several patients' (of ten) classified as false negative had 'palpable lymph nodes' |
| Broderick-Villa [62] |
2002 |
Learning curve strongly associated with false negative rate (67% in first half, 32% in second half). No significant association with T-stage, LN involvement or tumor diameter > or < 4 cm |
| Veihl [70] |
2003 |
Amount of dye relative to tumor size was an important predictor of identification of node. False negative more common in cases with larger nodes (4.5 cm v 3.4 cm, p = 0.09) |
| Bilchik [83] |
2006 |
Of the six false negatives, four were attributable to tumor obliteration of the lymphatic channels |
| Saha [85] |
2006 |
95% of patients with skip metastases were T3 or T4 |
| Thomas [87] |
2006 |
Two patients with liver metastases along with two others with gross mesenteric disease had false positive sentinel nodes. No relationship between BMI and disease |
|
|
||
| Kelder [89] |
2006 |
In one of the two false negatives, the non-SLNs were involved by extra-nodal tumor invasion |
| Bembenek [92] |
2007 |
Significant association with learning curve/center experience, BMI (cut-off level being 22 patients and a BMI of 25 respectively) & LVI. No significant association between detection and T stage, age, sex, vascular invasion, no of nodes, total no of nodes. |
| Sandrucci [93] |
2007 |
'Skip metastases' were all correlated with 'T2 lesions with massive lymphatic involvement' |
| Tiffet [94] |
2007 |
Three of 12 false negatives were in patients with direct tumor involvement of adjacent non-sentinel epicolic nodes while four were in N2 patients. False negative rate markedly lower in the subgroup with T1 and T2 tumors only. and in those with BMI < 30 kg/m2 |
Cahill et al. BMC Surgery 2008 8:17 doi:10.1186/1471-2482-8-17 |
||