Upper panels, hematoxylin and eosin staining. Panel (a) shows a low resolution (5 ×) image of the oncocytic transition from typical papillae (asterisk) and a hyperplastic-dysplastic state (cross) to malignant transformation (circle). Panel (b) shows a 10× enlargement of the undifferentiated carcinoma with a few atypical mitoses (arrows). Lower panels, immunohistochemistry anti-cytokeratin staining: panel (c) shows a 10× enlargement of the undifferentiated carcinoma immunoreactive to cytokeratin, and panel (d) a detail (40×) of a very atypical cell with cytoplasmic anti-cytokeratin immunoreactivity.
Ferrero et al. BMC Surgery 2003 3:1 doi:10.1186/1471-2482-3-1