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Changes in obesity-related diseases and biochemical variables after laparoscopic sleeve gastrectomy: a two-year follow-up study

Villy Våge1*, Vetle Aaberge Sande2, Gunnar Mellgren24, Camilla Laukeland1, Jan Behme1 and John Roger Andersen13

Author Affiliations

1 Department of Surgery, Førde Central Hospital, 6807 Førde, Norway

2 Department of Clinical Science, University of Bergen, 5020 Bergen, Norway

3 Department of Health, Sogn og Fjordane University College, 6803 Førde, Norway

4 Hormone Laboratory, Haukeland University Hospital, 5021 Bergen, Norway

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BMC Surgery 2014, 14:8  doi:10.1186/1471-2482-14-8

Published: 11 February 2014



To evaluate changes in obesity-related diseases and micronutrients after laparoscopic sleeve gastrectomy (LSG).


We started the procedure in May 2007, and by December 2011, 117 patients could be evaluated for a two year follow-up. Comparisons of preoperative status with 12 and 24 months postoperative status were made for body mass index (BMI), obesity-related diseases and micronutrients.


Major complications included bleeding requiring transfusion at 5.1%, leak at 1.7% and abscess without a visible leak at 0.9%. Mean BMI was reduced from 46.6 (standard deviation (SD) 6.0) kg/m2 to 30.6 (SD 5.6) kg/m2 at two years, and resolution occurred for 80.7% of patients with type 2 diabetes, 63.9% with hypertension, 75.8% with hyperlipidemia, 93.0% with sleep apnea, 31.4% with musculoskeletal pain, 85.4% with snoring and 73.3% with urinary incontinence. Amenorrhea resolved in all premenopausal females. The proportion of patients with symptomatic gastroesophageal reflux disease increased from 12.8% to 27.4%. The prevalence of patients with low ferritin-levels increased, while 25-hydroxyvitamin D (25(OH)D) deficiency decreased postoperatively.


LSG is an effective procedure for morbid obesity and obesity-related diseases, but the technique should be further explored particularly to avoid gastroesophageal reflux.

Sleeve gastrectomy; Obesity; Comorbidities; Complications