This article is part of the supplement: Selected articles from the XXV National Congress of the Italian Society of Geriatric Surgery
Use of statins in lower extremity artery disease: a review
1 Department of Clinical Medicine and Cardiovascular and Immunology Sciences, Federico II University, via Pansini 5, 80131, Naples, Italy
2 Department of Biology and Cellular and Molecular Pathology, Federico II University, via Pansini 5, 80131, Naples, Italy
3 Department of General, Geriatric, Oncologic Surgery and Advanced Technologies, Federico II University, via Pansini 5, 80131, Naples, Italy
Citation and License
BMC Surgery 2012, 12(Suppl 1):S15 doi:10.1186/1471-2482-12-S1-S15Published: 15 November 2012
Lower extremity artery disease (LE-PAD) is one of the most common manifestations of atherosclerosis, particularly in elderly patients, and it is related to a high cardiovascular risk.
It is well established that statin therapy is characterized by crucial benefits on cardiovascular system by limiting atherosclerotic progression and reducing cardiovascular events and mortality. A growing body of evidence support efficacy of statins in LE-PAD due to the ability of both reducing cardiovascular risk and improving walking distance and, hence, quality of life. Consequently, statin therapy should be considered in all LE-PAD patients and new LDL-cholesterol targets should be reached.
Our opinion is that statin therapy remains still underutilized or with inadequate dosage, so therapy of LE-PAD patients should be improved to obtain all the demonstrated benefits of statins.