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Open Access Research article

Prognostic analysis of combined curative resection of the stomach and liver lesions in 30 gastric cancer patients with synchronous liver metastases

Yan-Na Wang1, Kun-Tang Shen1*, Jia-Qian Ling1, Xiao-Dong Gao1, Ying-Yong Hou2, Xue-Fei Wang1, Jing Qin1, Yi-Hong Sun1 and Xin-Yu Qin1

Author Affiliations

1 Department of General Surgery, Zhongshan Hospital of Fudan University, No 180 Fenglin Road, Shanghai, 200032, China

2 Department of Pathology, Zhongshan Hospital of Fudan University, No 180 Fenglin Road, Shanghai, 200032, China

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BMC Surgery 2012, 12:20  doi:10.1186/1471-2482-12-20

Published: 12 October 2012

Abstract

Background

Gastric cancer with synchronous liver metastasis remains a clinical treatment challenge. There has been a longstanding debate on the question whether surgical resection could be beneficial to long-term survival. This study is to investigate the effectiveness and prognostic factors of combined curative resection of the stomach and liver lesions in gastric cancer patients with synchronous liver metastases.

Methods

A total of 30 patients who underwent simultaneous curative gastric and liver resection from March 2003 to April 2008 were analyzed retrospectively. Univariate and multivariate analyses were performed to select independent factors for survival.

Results

The overall 1-, 2-, 3- and 5-year survival rates of 30 patients were 43.3%, 30.0%, 16.7% and 16.7%, respectively, with a median survival of 11.0 months and 5 patients still living by the time of last follow-up. Single liver metastasis (p = 0.028) and an absence of peritoneal dissemination (p = 0.007) were significantly independent prognostic factors for these gastric cancer patients with synchronous liver metastases. Major adverse events were protracted stomach paralysis in 2 patients and pulmonary infection in another 2 patients, all of whom recovered after conservative treatment.

Conclusions

This descriptive study without control group found that patients with solitary liver metastasis and absence of peritoneal dissemination could have better survival benefit from simultaneous curative resection of the gastric cancer and liver metastases.

Keywords:
Gastric cancer; Liver metastases; Clinicopathological factors; Prognosis