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Open Access Research article

Bovine pericardium retail preserved in glutaraldehyde and used as a vascular patch

Wladimir F Saporito1, Adílson C Pires1, Sérgio H Cardoso1, João A Correa1, Luiz Carlos de Abreu2*, Vitor E Valenti23, Luciano MR Miller2 and Eduardo Colombari2

Author Affiliations

1 Departamento de Cirurgia and Laboratório de Escrita Científica, Departamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, Brasil

2 Laboratório de Escrita Científica, Departamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, Brasil

3 Departamento de Fonoaudiologia, Faculdade de Filosofia e Ciências, Universidade Estadual Paulista, UNESP, Marília, SP, Brasil

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BMC Surgery 2011, 11:37  doi:10.1186/1471-2482-11-37

Published: 22 December 2011

Abstract

Background

In this study we evaluated the performance of bovine pericardium preserved in glutaraldehyde used as a vascular patch.

Methods

Fourteen young pigs, six females and eight males, weighting 10.3 - 18.4 kg were used in our study. We implanted three remnants in each pig, two in the abdominal aorta and one was juxtaposed to the peritoneum. The smooth face (SF) and rough face (RF) of each remnant were implanted turned to the vessel inner portion and one remnant was juxtaposed to the peritoneum. The animals were sacrificed in 4.5 - 8 months after surgery (75 - 109 kg). The remnants were assessed for aorta wall, fibroses formation in inner apposition and calcification related to the face turned to the vessel inner portion.

Results

The rough face showed a lower dilatation level compared to the face implanted in adjacent aorta. There was no difference between intensity and/or incidence of graft calcification when the superficies were compared. The bovine pericardium preserved in glutaraldehyde did not show alterations in its structure when implanted with different faces turned to the inner portion of vessel.

Conclusion

When turned to the inner portion of the vessel, the rough face of the remnant presented a lower dilatation in relation to the adjacent aorta and a better quality of endothelium layer and did not show a difference between intensity and/or incidence of graft calcification.