Table 2

Definitions of isolated tumor cells (ITCs) and micrometastases (MMS)

Definitions used in EnRouteStudy

Isolated Tumor Cells (ITCs)

Micrometastases (MMs)


Size

< 0.2 mm

0.2 - 2 mm

Localization

No defining criterion

No defining criterion

Detection method

HES and/or IHC

HES and/or IHC

Formal designation (present vs absent)

pN0i+ vs pN0i-

pN0mi+ vs pN0mi-

Designation for study purposes if present

pN0micro+

pN0micro+


HES hematoxylin and eosin stain; IHC immunohistochemistry.

Lips et al. BMC Surgery 2011 11:11   doi:10.1186/1471-2482-11-11

Open Data