 Research articleThe effect of cartilage and bone density of mushroom-shaped, photooxidized, osteochondral transplants: an experimental study on graft performance in sheep using transplants originating from different speciesAnja C Waselau1 1 Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty Zurich, University of Zurich, Switzerland 2 Anesthesiology, Equine Hospital, Vetsuisse Faculty Zurich, University of Zurich, Switzerland 3 Veterinary Pathology, Vetsuisse Faculty Zurich, University of Zurich, Switzerland 4 Centerpulse Biologics, Winterthur, Switzerland
BMC Musculoskeletal Disorders 2005, 6:60doi:10.1186/1471-2474-6-60
Additional filesAdditional File 1: Groups of animals and distribution of osteochondral grafts within the groups. Format: PDF Size: 18KB Download file This file can be viewed with: Adobe Acrobat Reader Additional File 2: Semi-quantitative score system for histological assessment of synovial membrane sections. High numbers represent bad, low numbers good results. Format: PDF Size: 20KB Download file This file can be viewed with: Adobe Acrobat Reader Additional File 3: Semi-quantitative score system for histological assessment of cartilage sections. High numbers represent bad, low numbers good results. Format: PDF Size: 23KB Download file This file can be viewed with: Adobe Acrobat Reader Additional File 4: Results of macroscopic evaluation of grafts at the time of sacrifice (6 months). Overall, the equine (EN) together with the old bovine (BO) grafts retained the blue color the most, and only 2 grafts were partially overgrown by pannus-like tissue. Only 1/8 equine grafts was slightly sunk into the original cartilage defect. Format: PDF Size: 20KB Download file This file can be viewed with: Adobe Acrobat Reader Additional File 5: Radiographic evaluation of osteochondral transplants at the time of sacrifice (6 months). Format: PDF Size: 19KB Download file This file can be viewed with: Adobe Acrobat Reader Additional File 6: Results of semi-quantitative histological evaluation of synovial membrane samples. Scores for a) degenerative aspects: 0 = none, 1 = mild, 2 = moderate, 3 = severe and b) regenerative aspects: 0 = good, 1 = medium, 2 = few, 3 = none. Note that most of the membranes are within physiological limits and only those of the human transplants show immunogenic reactions. Format: PDF Size: 24KB Download file This file can be viewed with: Adobe Acrobat Reader Additional File 7: Overview of statistical results (cartilage and subchondral bone) and results of semi-quantitative histological evaluation of cartilage samples. The equine group (EN) accumulates most of the best ( = lowest scores) and second best scores. Most of the lowest scores were found in the human group according to the old process (HO). Scores for a) degenerative aspects: 0 = none, 1 = mild, 2 = moderate, 3 = severe and b) regenerative aspects: 0 = good, 1 = medium, 2 = few, 3 = none. Low scores represent good results, while high scores mean less good results. Colors indicate performance Format: PDF Size: 28KB Download file This file can be viewed with: Adobe Acrobat Reader Additional File 8: Results of the histomorphometrical measurements. The equine group (EN) showed the highest percentage of bone and the least amount of cystic lesions. Format: PDF Size: 19KB Download file This file can be viewed with: Adobe Acrobat Reader |
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