|
Number (%) of adverse events |
||
| Adverse Event |
Topical diclofenac (n = 107) |
Vehicle control (n = 109) |
|
|
||
| Gastrointestinal reaction |
||
|
|
||
| Abdominal pain |
4 (3.7) |
1 (0.9) |
| Constipation |
1 (0.9) |
1 (0.9) |
| Diarrhea |
1 (0.9) |
0 |
| Dyspepsia |
4 (3.7) |
1 (0.9) |
| Gastritis |
1 (0.9) |
0 |
| Melena |
0 |
1 (0.9) |
| Nausea |
1 (0.9) |
2 (1.8) |
|
|
||
| Application-site skin reaction |
||
|
|
||
| Dry skin |
42 (39.3)* |
23 (21.1) |
| Rash |
2 (1.9) |
4 (3.7) |
| Paresthesia |
2 (1.9) |
2 (1.8) |
| Pruritus |
0 |
2 (1.8) |
|
|
||
| Other reaction |
||
|
|
||
| Headache |
6 (5.6) |
10 (9.2) |
| Halitosis |
2 (1.9) |
0 |
| Taste Perversion |
4 (3.7) |
2 (1.8) |
|
*p < 0.01 vs. vehicle control | ||
Baer et al. BMC Musculoskeletal Disorders 2005 6:44 doi:10.1186/1471-2474-6-44 |
||