Open Access Research article

Serum prolidase activity in benign joint hypermobility syndrome

Serda Em1*, Demet Ucar1, Pelin Oktayoglu1, Mehtap Bozkurt1, Mehmet Caglayan1, Ismail Yıldız2, Osman Evliyaoglu3 and Kemal Nas1

Author Affiliations

1 Department of Physical Medicine and Rehabilition, Division of Rheumatology, Dicle University Faculty of Medicine, Diyarbakir, Turkey

2 Department of Biostatistics, Dicle University Faculty of Medicine, Diyarbakir, Turkey

3 Department of Biochemistry, Dicle University Faculty of Medicine, Diyarbakir, Turkey

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BMC Musculoskeletal Disorders 2014, 15:75  doi:10.1186/1471-2474-15-75

Published: 11 March 2014



Moderate joint laxity is widespread in many joints of the body, and this condition is considered to be caused by an abnormality in the collagen structure. This study was carried out to determine the serum prolidase activity in female patients with benign joint hypermobility syndrome (BJHS), and to evaluate its correlation with their clinical features.


A total of 45 patients with BJHS and 40 healthy controls were included in the study. All of the patients with BJHS met the Beighton diagnostic criteria. All the patients and the control group underwent a comprehensive examination of the locomotor system and took the New York Posture Rating Test. The examination and test results were recorded. Serum prolidase activity was measured in both the groups.


Prolidase activity was significantly lower in patients with BJHS (479.52 ± 126.50) compared to the healthy controls (555.97 ± 128.77) (p = 0.007). We found no correlation between serum prolidase activity and Beighton scores or New York rating test scores. On the other hand, mean prolidase activity was significantly lower in patients with pes planus or hyperlordosis compared to those without (p = 0.05, p = 0.03, respectively). We did not find such a correlation with the other clinical features.


Significantly lower prolidase activity in patients with BJHS suggests that prolidase may affect the collagen metabolism and cause hyperlaxity.

Hypermobility; Prolidase; Ligament; New York rating test