Effect of HP-R1, HP-R2 and HP-R3 on paw swelling of AA rats. Adjuvant Arthritis was induced on day 0 with Freund’s Complete Adjuvant (FCA). 100 μg peptides were administered nasally by micropipette on day 10, 13, 16, and 19 after FCA injection. An equal volume of PBS was given rats in control group and AA model group. Paw swelling was assessed when arthritis score reached a maximum on day 28. Data are presented as mean ± SEM, n =9 rats per group. *P < 0.05 when compared to control group, ##P < 0.01 when compared to AA group.
Shi et al. BMC Musculoskeletal Disorders 2014 15:253 doi:10.1186/1471-2474-15-253