Email updates

Keep up to date with the latest news and content from BMC Musculoskeletal Disorders and BioMed Central.

Open Access Research article

High disease activity in ankylosing spondylitis is associated with increased serum sclerostin level and decreased wingless protein-3a signaling but is not linked with greater structural damage

Mariusz Korkosz1*, Jerzy Gąsowski2, Piotr Leszczyński3, Katarzyna Pawlak-Buś3, Sławomir Jeka4, Ewa Kucharska5 and Tomasz Grodzicki2

Author Affiliations

1 Division of Rheumatology, Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Polish Spondyloarthritis Initiative, Kraków, Poland

2 Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Polish Spondyloarthritis Initiative, Kraków, Poland

3 Department of Rheumatology and Rehabilitation, University of Medical Sciences, Poznań, Poland

4 Department of Rheumatology and Connective Tissue Diseases, 2nd University Hospital, Bydgoszcz, Poland

5 Vadimed Clinic, Kraków, Poland

For all author emails, please log on.

BMC Musculoskeletal Disorders 2013, 14:99  doi:10.1186/1471-2474-14-99

Published: 19 March 2013

Abstract

Background

Clinical activity of ankylosing spondylitis (AS) predicts the natural course of the disease and the response to treatment. Several molecules are involved in new bone formation resulting in structural damage in patients with AS. However, the link between the clinical and molecular phenomena has not yet been fully established. The aim of the study was to investigate the relation between markers of bone remodeling and inflammation with clinical activity and structural damage in AS.

Methods

We assessed the serum levels of sclerostin, Dickkopf-1 protein, Wingless protein-3a, bone morphogenic protein-7, matrix metalloproteinase-3, osteoprotegerin, bone alkaline phosphatase and inflammatory markers in 50 AS patients with high disease activity (BASDAI ≥ 4), 28 with low disease activity (BASDAI <4), and 23 healthy controls. Cervical and lumbar spine x-rays were performed in 46 patients to measure structural damage (mSASSS).

Results

Sclerostin level was significantly greater in high disease activity patients than in controls. Wingless protein-3a and Dikkopf-1 protein levels were significantly lower in high activity group compared to low activity group and controls. Negative correlation was found between sclerostin and Dikkopf-1 protein in high activity group (R = −0.28, P = 0.048). The median mSASSS values were not different between patient groups.

Conclusions

Higher disease activity in AS may not be per se associated with greater new bone formation.

Keywords:
Ankylosing spondylitis; BASDAI; New bone formation; Sclerostin; Wnt