Histology of specimens revised in Group 1 (a, b), Group 2 (c, d) and Group 3 (e, f); sections are representative of bone tissue at increasing distances from the HR dome: within 0.8 cm (top) (a, c, e), from 1.6 to 2.4 cm (b, d, f) (bottom). Toluidine Blue, Acid Fuchsin, Fast Green staining. a) trabecular lamellar bone with evident evenly-spread osteocytes, orientated with the longest axis in the direction of the lamellae contained in the bone lacunae (arrows), resolution 20x; b) necrotic bone tissue, resolution 10x; c) necrotic tissue, resolution 20x; d) necrotic bone tissue infiltrated with aggregates of small dark metal wear-debris particles (metallosis) (arrows), resolution 10x; e) loss of normal trabecular bone microarchitecture, uneven edges due to the resorption of necrotic bone (arrows) resolution 20x; f) metallosis in close association with the necrotic bone trabeculae, resolution 10x.
Salamanna et al. BMC Musculoskeletal Disorders 2013 14:47 doi:10.1186/1471-2474-14-47