Table 2

Rooney’s inflammation scoring system for patients with rheumatoid arthritis
Score
Histologic feature 0 1 2 3 4 5 6 7 8 9 10
Synoviocyte hyperplasiaa 1 2 3 4 5 6 7 8 9 10 >10
Fibrosisb <10 <15 <20 <25 <30 <40 <50 <60 <70 <80 ≥80
Proliferating blood vesselsc 0–3 4–5 6–7 8–9 10–11 12–13 14–15 16–17 18–19 20–22 >22
Perivascular infiltrates of lymphocytesd <5 10 20 30 40 50 60 70 80 90 100
Focal aggregates of lymphocytese <11 15 20 25 30 35 40 45 50 55 >55
Diffuse infiltrates of lymphocytesf 0 10 20 30 40 50 60 70 80 90 100

aA normal synoviocyte monolayer was scored as 0. The score was increased as the synoviocyte lining layer increased in depth. bSections containing < 10% fibrous tissue in the sublining layers were scored as 0. The score increased as the percentage of fibrosis in the section increased. cThree or fewer vessels per high power field (HPF) were scored as 0. The score increased as the number of vessels per HPF increased. dWhen no lymphocytes were observed around vessels, it was scored as 0. The score increased as the percentage of vessels surrounded by lymphocytes increased. Subsequently, the diameter of the perivascular lymphocytes was graded as mild = 2–4 cells in diameter, moderate = 5–7 cells in diameter, and severe = 8–10 cells in diameter. Where the perivascular lymphocytes were considered mild or severe, the original score was lowered by 1 point or raised by 1 point, respectively. eAbsence of focal aggregates of lymphocytes, which exceeded 10 cells in diameter, were scored as 0. The score increased as the cell numbers in the diameter of the focal aggregates increased. fAn estimate was made of the percentage of cells per HPF that were lymphocytes. The score increased as the percentage of lymphocytes increased.

Takagawa et al.

Takagawa et al. BMC Musculoskeletal Disorders 2013 14:40   doi:10.1186/1471-2474-14-40

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