Open Access Research article

Decreased Semaphorin3A expression correlates with disease activity and histological features of rheumatoid arthritis

Shu Takagawa1, Fumio Nakamura2*, Ken Kumagai1, Yoji Nagashima3, Yoshio Goshima2 and Tomoyuki Saito1*

Author Affiliations

1 Department of Orthopaedic Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan

2 Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan

3 Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan

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BMC Musculoskeletal Disorders 2013, 14:40  doi:10.1186/1471-2474-14-40

Published: 23 January 2013

Additional files

Additional file 1:

Expression of VEGF165 mRNA in synovial tissues: preliminary study. Expression levels of VEGF165 mRNA were measured by real-time PCR. The mRNA levels were normalized to the expression of β-actin. The box plots demonstrate the 10th and 90th percentile (whiskers), the 25th and 75th percentile, and the median. VEGF165 mRNA levels were not significantly altered in RA (n = 25) synovial tissues compared with OA (n = 17) (A). VEGF165 expression levels did not significantly correlate with DAS28-CRP. (B)

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