Table 1

Frequency and percentage of animals with histopathological findings in muscle fiber
Week 2 Week 3 Week 5 Week 9
(N = 5) (N = 5) (N = 6) (N = 6)
# % # % # % # %
Necrosis 2 40 1 20 0 0 0 0
Degeneration 1 20 3 60 6 100 5 83
Atrophy 0 0 3 60 4 67 4 67
Regeneration 0 0 0 0 3 50 1 17

#: Number of the animals with the histopathological finding.

%: Percentage of the animals with the histopathological finding

As for degeneration, necrosis, or regeneration of muscle fiber, when a few mass or affected muscle bundles were observed in several scattered areas, the finding was judged positive. Atrophy was diagnosed when width of the muscle bundle was smaller than half width of normal bundle. The number of animals with the above lesions was summarized in Table 1.

Horai et al.

Horai et al. BMC Musculoskeletal Disorders 2013 14:205   doi:10.1186/1471-2474-14-205

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