Trabecular bone made up by remodeling with reactive bone formation (A) and reduction or disappearance of inter-trabecular spaces (B). Some residual inter-trabecular space shows micro-aggregation of granulocytes, expression of an acute inflammatory process (C), while other inter-trabecular spaces are filled up with bone matrix and fibrosis (D). At the periphery of the bone, in the sub-synovial tissue, fibrosis with chronic flogosis around bone debris may be observed (E).
Manzi et al. BMC Musculoskeletal Disorders 2012 13:50 doi:10.1186/1471-2474-13-50