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The relationship between retinal vessel calibre and knee cartilage and BMLs

Miranda L Davies-Tuck1, Ryo Kawasaki2, Anita E Wluka13, Tien Y Wong24, Lauren Hodgson2, Dallas R English56, Graham G Giles56 and Flavia Cicuttini1*

Author Affiliations

1 Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, VIC, 3004, Australia

2 Department of Ophthalmology, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, East Melbourne, VIC, 3002, Australia

3 Baker Heart Research Institute, Melbourne, Australia

4 Singapore Eye Research Institute, National University of Singapore, Singapore, Singapore

5 Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Carlton, VIC, 3053, Australia

6 Cancer Epidemiology Centre, The Cancer Council of Victoria, Carlton, VIC, 3053, Australia

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BMC Musculoskeletal Disorders 2012, 13:255  doi:10.1186/1471-2474-13-255

Published: 20 December 2012



Whether the increase in vascular disease prevalence and mortality in OA populations is a result of co-occurrence of cardiovascular disease and OA, which are both common in the older population, is due to OA treatments or to the common association with reduced physical activity and/or obesity is unclear. One way to explore this non-invasively is to examine the cross-sectional relationship between changes in retinal microvasculature, which have been shown to be markers of generalized vascular pathology, and knee structural changes in an asymptomatic community-based population.


A community sample of 289 (61% women) aged 50–79 years with no knee symptoms underwent magnetic resonance imaging (MRI) of their dominant knee in 2003. Cartilage volume and bone marrow lesions (BMLs) were determined. All subjects also had retinal photographs taken from which retinal arteriolar and venular diameters were determined and summarized as the central retinal arteriolar equivalent (CRAE) and the central retinal venular equivalent (CRVE).


Retinal venular diameter was significantly wider in subjects with a BML compared with subjects without a BML (mean (SD) 214.2 (2.8) μm versus 207.5 (1.1) μm respectively independent of age, gender and BMI. A trend for decreased medial tibial cartilage with increasing CRAE was also observed (regression coefficient −2.70 μl, 95%CI-5.74, 0.5, p=0.08).


These findings suggest that vascular pathology, indicative of inflammatory processes, is associated with early structural knee changes. The role of micro-vascular changes in the pathogenesis of OA warrants further investigation.