Table 1

Description of treatment conditions and semi-quantitative measurement of bone and marrow formation in scaffold constructs and pellets.

Donor

Treatment

Implanted

Bone formed

% Bone

% Marrow


1

Control in scaffold

3

0/3

0

0

Osteogenic in scaffold

3

0/3

0

0

Chondrogenic in scaffold

3

3/3

9 ± 3

8 ± 7

Switch 1 (switch to osteogenic culture) in scaffold

3

0/3

0

0


2

Control in scaffold

3

0/3

0

0

Osteogenic in scaffold

3

0/3

0

0

Chondrogenic in scaffold

3

2/3

13 ± 7

6 ± 7

Switch 1 (switch to osteogenic culture) in scaffold

3

0/3

0

0


3

Chondrogenic in scaffold

3*

Switch 1 (switch to osteogenic culture) in scaffold

3*

Switch 2 (+β-glycerophosphate) in scaffold

3*


3

Chondrogenic in pellet

3

3/3

32 ± 10

37 ± 24

Switch 1 (switch to osteogenic culture) in pellet

3

0/2

0

0

Switch 2 (+β-glycerophosphate) in pellet

3

1/1

23

52

14 weeks chondrogenic in pellet

3

2/2

24 ± 7

76 ± 7


Results are average ± SD. *Donor 3 scaffolds were not analysed because of poor cell seeding as determined in pre-implantation samples by histology and RNA content.

Farrell et al. BMC Musculoskeletal Disorders 2011 12:31   doi:10.1186/1471-2474-12-31

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