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Open Access Highly Accessed Research article

Bone metastases from renal cell carcinoma: patient survival after surgical treatment

Andreas Fottner1*, Melinda Szalantzy1, Lilly Wirthmann1, Michael Stähler2, Andrea Baur-Melnyk3, Volkmar Jansson1 and Hans Roland Dürr1

Author Affiliations

1 Department of Orthopaedic Surgery, Campus Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr 15, 81377 Munich, Germany

2 Department of Urology, Campus Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr 15, 81377 Munich, Germany

3 Department of Radiology, Campus Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr 15, 81377 Munich, Germany

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BMC Musculoskeletal Disorders 2010, 11:145  doi:10.1186/1471-2474-11-145

Published: 3 July 2010

Abstract

Background

Surgery is the primary treatment of skeletal metastases from renal cell carcinoma, because radiation and chemotherapy frequently are not effecting the survival. We therefore explored factors potentially affecting the survival of patients after surgical treatment.

Methods

We retrospectively reviewed 101 patients operatively treated for skeletal metastases of renal cell carcinoma between 1980 and 2005. Overall survival was calculated using the Kaplan-Meier method. The effects of different variables were evaluated using a log-rank test.

Results

27 patients had a solitary bone metastasis, 20 patients multiple bone metastases and 54 patients had concomitant visceral metastases. The overall survival was 58% at 1 year, 37% at 2 years and 12% at 5 years. Patients with solitary bone metastases had a better survival (p < 0.001) compared to patients with multiple metastases. Age younger than 65 years (p = 0.036), absence of pathologic fractures (p < 0.001) and tumor-free resection margins (p = 0.028) predicted higher survival. Gender, location of metastases, time between diagnosis of renal cell carcinoma and treatment of metastatic disease, incidence of local recurrence, radiation and chemotherapy did not influence survival.

Conclusions

The data suggest that patients with a solitary metastasis or a limited number of resectable metastases are candidates for wide resections. As radiation and chemotherapy are ineffective in most patients, surgery is a better option to achieve local tumor control and increase the survival.