Table 1

Case Data Summaries

Pt. No

Sex, Age (Years)

NTM Species

Radiographic Pattern

Duration of therapy prior to starting amikacin (months)

Amikacin Therapeutic Regimen

Duration of Inhaled Amikacin (months)

Current Therapeutic Regimen

Current Patient Status

Current Sputum Culture Status


1

F, 73

MAC

nodular infiltrates, bronchiectasis in RUL, RML, lingula

96

CLA, RIF, EMB, inhaled amikacin

9

no oral antibiotics since 7/05; no inhaled amikacin since 6/06.

rare cough, wt loss, sweats, fatigue; abdominal cramps

negative for 21 months; now positive (MAC)

2

F, 67

MAC

bilateral bronchiectasis, cavitary lesion RUL and bilateral apical fibrosis/scarring

12

AZI, RIF, EMB, inhaled amikacin

4

n/a

progressive disease; died

persistent positive at death

3

F, 66

MAC, M. chelonae

bronchiectasis RML, RLL, LLL, lingula; bilateral apical fibrosis/scarring, centrilobular nodules

48

AZI, RIF, EMB, inhaled amikacin

52

AZI 500 mg/d since 4/06

status post multiple lobectomies; cough and exertional dyspnea; daily low grade fevers

negative for 6 months., now positive; M. chelonae (resistant to amikacin

4

F, 71

MAC

bronchiectasis and centrilobular nodules in posterior segments of both upper lobes, RML, lingula and lower lobes

36

CLA, inhaled amikacin

16

no antibiotics since 11/05

rare cough

negative for 7 months; now positive; MAC (resistant to EMB, RIF)

5

F, 52

MAC, M. chelonae

LUL wedge resection for MAC; bronchiectasis in LLL, RUL; R apical scarring, nodules in LLL, LUL, lingula

0.5

AZI, inhaled amikacin (thrombocytopenia on RIF/EMB)

13

inhaled amikacin 1000 mg/d and AZI 250 mg/d since 5/05

improved with some cough, no purulence

negative for 6 mo.

6

F, 54

MAC

bronchiectasis w/bronchial wall thickening RLL, RUL.

13

AZI, inhaled amikacin

8

AZI 500 mg 2/wk, inhaled amikacin 1000 mg 3/wk

rare cough, clinically well

no cough sputum (despite sputum induction)


Abbreviations: AZI (azithromycin); CIP (ciprofloxacin); CLA (clarithromycin); EMB (ethambutol); RIF(rifampin); RUL (right upper lobe); RML (right middle lobe); RLL (right lower lobe); LLL (left lower lobe)

Davis et al. BMC Pulmonary Medicine 2007 7:2   doi:10.1186/1471-2466-7-2

Open Data