Table 1

Baseline demographics and clinical characteristics (safety population)
Glycopyrronium bromide 12.5 μg OD (n = 89) Glycopyrronium bromide 25 μg OD (n = 96) Glycopyrronium bromide 12.5 μg BID (n = 96) Glycopyrronium bromide 50 μg OD (n = 92) Glycopyrronium bromide 25 μg BID (n = 96) Glycopyrronium bromide 100 μg OD (n = 96) Glycopyrronium bromide 50 μg BID (n = 87) Placebo (n = 91)
Age (years), mean (SD) 60.2 (7.77) 60.0 (7.98) 60.9 (7.89) 59.2 (8.14) 61.2 (7.80) 62.1 (7.83) 62.2 (7.74) 63.2 (7.67)
Range 47-79 43-81 40-80 43-80 40-80 40-79 49-81 48-78
Sex, n (%)
Male 56 (62.9) 64 (66.7) 67 (69.8) 56 (60.9) 66 (68.8) 59 (61.5) 59 (67.8) 56 (61.5)
Smoking history, n (%)
Ex-smoker 45 (50.6) 51 (52.1) 50 (52.1) 45 (48.9) 50 (52.1) 57 (59.4) 48 (55.2) 52 (57.1)
Current smoker 44 (49.4) 45 (46.9) 46 (47.9) 47 (51.1) 46 (47.9) 39 (40.6) 39 (44.8) 39 (42.9)
Pack-years, mean (SD) 43.2 (23.05) 39.6 (19.97) 40.9 (19.88) 39.3 (19.91) 42.8 (23.26) 39.8 (19.79) 42.1 (21.17) 40.4 (20.84)
FEV1 pre-bronchodilator (% predicted), n (%)
47 (12) 46 (11) 46 (14) 46 (11) 45 (12) 46 (14) 48 (13) 48 (13)
FEV1 post-bronchodilator (% predicted), n (%)
30- < 50% 34 (38.2) 36 (37.5) 44 (45.8) 34 (37.0) 43 (44.8) 44 (45.8) 34 (39.1) 37 (40.7)
50- < 80% 55 (61.8) 60 (62.5) 52 (54.2) 58 (63.0) 53 (55.2) 52 (54.2) 53 (60.9) 54 (59.3)
FEV1 reversibility,%
Mean (SD) 17 (12) 19 (16) 16 (14) 17 (12) 16 (12) 17 (18) 16 (16) 16 (16)
Median (range) 16 (−11-44) 19 (−16-90) 16 (−43-55) 18 (−18-40) 15 (−13-44) 16 (−43-72) 14 (−21-90) 13(−21-72)
FEV1/FVC (%) post-bronchodilator (%), mean (SD)
46.87 (10.36) 46.76 (8.66) 45.86 (11.12) 46.41 (9.29) 46.15 (10.21) 47.21 (11.72) 47.89 (9.57) 48.22 (10.65)

OD: once daily; BID: twice daily; SD: standard deviation; FEV1: forced expiratory volume in one second; FVC: forced vital capacity.

Arievich et al.

Arievich et al. BMC Pulmonary Medicine 2012 12:74   doi:10.1186/1471-2466-12-74

Open Data